High
NA
$30/day
Renally cleared, requires dosage adjustment with changes in renal function. Consult a pharmacist for renal dosing.
Severe enteric fever50 mg/kg/dose IV q8h x 10-14 days
Leptospirosis, N meningitis50 mg/kg/dose IV q6h x 7 days
H inf B meningitis, S pneumonia meningitis, GBS meningitis50 mg/kg/dose IV q6h x 14 days
G - meningitis50 mg/kg/dose IV q6h x 21 days
IE50 mg/kg/dose IV q6h x 4-6 wk
Empiric therapy for bacterial meningitis, pneumonia, intra-abdominal infection (with metronidazole), and urinary tract infection
Rash
Localized phlebitis at injection site
Allergy
Positive Coombs test
Neutropenia
Diarrhea
Antimicrobial class: 3rd Generation Cephalosporin
Average serum half life:
Neonates: 3.4-4.6 hours
Children: 1.5 hours
Route of Elimination: Urine: ~60% as unchanged drug and metabolites in urine
