Spectrum: Local Antimicrobial Stewardship, for Yangon Children's Hospital

Artesunate + Mefloquine

Treatment

Artesunate 50mg tablet

AND

Mefloquine 250mg base tablet

Dosing

Body Weight of 3-10 kg:

  • Artesunate 1/2 tablet od

  • Mefloquine 1/2 tablet on day 2 only

Body Weight of >10 kg:

  • Artesunate 1 tablet od

  • Mefloquine 1 tablet on day 2 only

Duration of Therapy

3 days

Notes

Target Dose:

  • 4 mg/kg/day Artesunate od for 3 days

  • 25 mg/kg Mefloquine split over 2 days (as 15mg/kg and 10 mg/kg), OR 8/3 mg/kg/day od for 3 days

Therapeutic dose range:

  • 2-10 mg/kg/day Artesunate

  • 7-11 mg/kg/day Mefloquine