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Guidelines
Pathogens
Antimicrobials
Look for and manage predisposing factors, such as underlying venous stasis, tinea pedis. Consider consultation with Wound Care when appropriate.
Remember that it often takes at least 48 hours before improvements are seen in erythema/edema.
5 days depending upon clinical response
Oral Treatment
Cephalexin 500-1000mg PO QID
OR
IV Treatment
Cefazolin 1-2g IV q8h
Consider IV treatment for patients with systemic signs of infection or who cannot tolerate oral therapy.
Consider Infectious Diseases consultation in patients who are immunocompromised, history of penetrating injury, recent freshwater or saltwater exposure or with severe skin and soft tissue infections, to assist with empiric antimicrobial therapy.
Moxifloxacin 400mg PO once daily
Clindamycin 300-600mg PO QID
Vancomycin 25mg/kg IV load followed by 15mg/kg IV maintenance dosing.
Consider using IV vancomycin in patients who are systemically unwell and cannot tolerate oral therapy.
View vancomycin nomogram.
Day 3 bundle