Spectrum: Local Antimicrobial Stewardship, for Saskatchewan Health Authority - Saskatoon Area

Cefazolin

C. diff Risk

Medium

Oral Bioavailability

NA

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Renal

Adult

Usual Dosing
1-2g IV q8h (max 6 g/day)

Skin and Soft Tissue Infections
1g IV q8h

MSSA Bacteremia OR Infective Endocarditis OR Osteomyelitis
2g IV q8h

General Information

Common Usage

Common Usage

Cefazolin is often used in treatment for skin and soft tissue infections, providing coverage for MSSA and beta-hemolytic Streptococcus spp.

Cefazolin is also used in treatment of deep space, invasive infections such as osteomyelitis and infective endocarditis, secondary to MSSA.

Adverse Effects

Adverse Effects

Allergy/rash

Cefazolin can be associated with a positive Coombs test, cytopenias, as well as hepatic and renal laboratory abnormalities.

Clostridium difficile associated diarrhea

Pharmacology

Pharmacology

Antimicrobial class: 1st Generation Cephalosporin

Pregnancy category: B

Average serum half life: 2 hours

Biliary penetration: Therapeutic

CSF penetration: Poor

Lung penetration: Therapeutic

Urine penetration: Therapeutic