Spectrum: Local Antimicrobial Stewardship, for Saskatchewan Health Authority - Saskatoon Area

MSSA

Initial Empiric Treatment

Cloxacillin 2g IV q4h

OR

Cefazolin 2g IV q8h

Duration of Therapy

Short duration of therapy of two weeks (from the first negative blood culture) should only be provided to patients meeting all of the following criteria for uncomplicated Staphylococcus aureus bacteremia.

  • Infective endocarditis has been excluded

  • No implanted prostheses are present

  • Follow up blood cultures drawn 2-4 days after the initial set are sterile

  • The patient defervesces within 72 hours of initiation of effective antibiotic therapy

  • No evidence of metastatic infection is present on examination

Longer treatment duration is needed for patients who have complicated Staphylococcus aureus bacteremia. Strongly consider consultation with Infectious Diseases.

Monitoring