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Guidelines
Pathogens
Antimicrobials
SIX weeks for left sided and complicated right sided IE
Shorter durations acceptable for uncomplicated right sided MSSA IE - discuss with ID
The course starts from the first negative blood culture, and may require alteration if complications occur or the patient requires surgery/valve replacement
Cloxacillin 2g IV q4H
Cefazolin 2g IV q8h
Vancomycin 25-30mg/kg IV load (max 2g) followed by 15mg/kg IV q12h maintenance for a target trough of 15-20µg/mL
Review nature of allergy and consider desensitization procedure for a penicillin/cephalosporin (optimal therapy)
Desensitization procedure
Drug to which patient has an immediate hypersensitivity reaction, is administered in increasing increments to allow TEMPORARY tolerance of the drug for a period of required therapy.
