Spectrum: Local Antimicrobial Stewardship, for AHS Calgary Zone

Cloxacillin

C. diff Risk

Medium

Oral Bioavailability

NA

Approximate Cost

$10/day

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Adult

2g IV q4-6h

General Information

Common Usage

Common Usage

Treatment of MSSA infections

Adverse Effects

Adverse Effects

  • Allergy (immediate or delayed)

  • Phlebitis at injection site in a peripheral vein

  • Cytopenias

  • Eosinophilia

  • Interstitial nephritis

  • Abnormal liver enzymes

Major Interactions

Major Interactions

Can increase methotrexate levels

Decrease mycophenolate levels

Tetracyclines can diminish cloxacillin activity

Pharmacology

Pharmacology

Antimicrobial class: Antistaphylococcal penicillin

Pregnancy category: B

Average serum half life: 1.0

Biliary penetration: Moderate

Lung penetration: Therapeutic

Urine penetration: Therapeutic