Spectrum: Local Antimicrobial Stewardship, for Fraser Health

Moderate DFI

Duration of therapy

≥14 days

Duration information

Empiric Treatment

Amoxicillin-clavulanate 875-125 mg one tab PO BID

(If no osteomyelitis or septic arthritis present)

OR

Ceftriaxone 2 g IV q24h

+/-

Metronidazole 500 mg PO/IV q12h

AND

If MRSA suspected:

TMP/SMX DS 1-2 tab PO BID

OR

Doxycycline 100 mg PO BID

OR

Vancomycin

MRSA coverage can be discontinued after 48 hours if cultures don’t show MRSA

Severe beta-lactam allergy

Moxifloxacin 400 mg PO q24h

OR

Clindamycin 450 mg PO TID

AND

Ciprofloxacin 500 mg PO BID