Spectrum: Local Antimicrobial Stewardship, for Fraser Health

Moderate-severe infection (outpatient)

Duration of therapy

7 days

Empiric Treatment

Cefazolin 2 g IV q24h

AND

Probenecid 1 g PO daily (give prior to cefazolin)

Second line

Ceftriaxone 1-2 g IV q24h

Severe beta-lactam allergy

Clindamycin 900 mg IV q12h

OR

Vancomycin 1 g IV q12h

Note

Reassess daily for PO stepdown (fever resolved, no further progression of erythema, improving pain)

Consider Infectious Diseases consultation if not improving after three days of therapy