Spectrum: Local Antimicrobial Stewardship, for Fraser Health

Intra-Abdominal or Hepatobiliary

POTENTIAL SEPSIS WITHOUT LIFE-THREATENING ORGAN DYSFUNCTION

Criteria

SIRS + potential infection + NO evidence of life-threatening organ dysfunction (below)

Piperacillin-tazobactam 3.375 g IV q6h

OR, IF ESBL RISK FACTORS:

Meropenem 500 mg IV q6h

SEPSIS WITH LIFE-THREATENING ORGAN DYSFUNCTION

Criteria

Two or more of (qSOFA):
1. Respiratory rate ≥ 22/min
2. Altered mentation
3. Systolic blood pressure ≤ 100 mmHg
OR
Lactate greater than 4 mmol/L

Meropenem 500 mg IV q6h

AND

Vancomycin