Spectrum: Local Antimicrobial Stewardship, for Fraser Health

Febrile Neutropenia

POTENTIAL SEPSIS without life-threatening organ dysfunction

Criteria

SIRS + potential infection + NO evidence of life-threatening organ dysfunction (below)

Piperacillin-tazobactam 4.5 g IV q6h

AND

Vancomycin

SEPSIS with life-threatening organ dysfunction

Criteria

Two or more of (qSOFA):
1. Respiratory rate ≥ 22/min
2. Altered mentation
3. Systolic blood pressure ≤ 100 mmHg
OR
Lactate greater than 4 mmol/L

Meropenem 500 mg IV q6h

AND

Vancomycin