Spectrum: Local Antimicrobial Stewardship, for Billings Clinic

Antibiotic De-Escalation

Serial PCT Monitoring

Repeat PCT level only if new or worsening respiratory based infection.

Consider initiation or modification of antibiotic therapy if no improvement in PCT level.

Note

Consider continuing antibiotic therapy if patient clinically unstable, regardless of PCT level.

Interpreting PCT Levels

<0.10μg/L or drop by >90%

Antibiotic cessation strongly encouraged

0.10-0.24μg/L or drop by >80%

Antibiotic cessation encouraged

0.25-0.49 μg/L

Antibiotic cessation discouraged

≥0.5 μg/L

Antibiotic cessation strongly discouraged