Spectrum: Local Antimicrobial Stewardship, for Billings Clinic

Ceftriaxone

C. diff Risk

High

Oral Bioavailability

NA

Approximate Cost

$2-3/day

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Renal

No adjustment required

Pediatric

Standard Dose
50 mg/kg IV/IM q24h

High Dose (meningitis)
100 mg/kg/day IV divided q12h

Adult

Usual dose: 2 g IV q24h

Bacterial meningitis: 2 g IV q12h

Enterococcal endocarditis with Ampicillin: 2 g IV q12h

General Information

Common Usage

Common Usage

Empiric therapy of:

  • Bacterial meningitis

  • Spontaneous bacterial peritonitis

  • Urinary tract infection and pyelonephritis

  •  Hospitalized, community or nursing home acquired pneumonia in combination with a macrolide

Drug Monitoring

Drug Monitoring

Long term therapy: weekly CBC and CMP

Adverse Effects

Adverse Effects

  •  Allergy/rash (immediate or delayed)

  •  Cytopenias

  •  Eosinophilia

  •  Hepatic & renal laboratory abnormalities

  •  Pseudocholelithiasis. Unclear clinical significance. Uncommonly symptomatic, but frequently by ultrasound gallbladder sludge.

Pharmacology

Pharmacology

Antimicrobial class: Parenteral Cephalosporin - 3rd Generation

Pregnancy category: B

Average serum half life: 8 hours

Biliary penetration: Therapeutic

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic