Gram positive

•  Group A,B,C,G,F Streptococci

•  S. pneumoniae

•  Viridans Streptococci

Gram negative

•  Most Enterobacteriaceae

•  H. influenzae

•  M catarrhalis

•  Pasteurella spp

Anaerobes

•  Prevotella melaninogenica

•  Peptostreptococci

Does not cover

•  Enterococci

•  B. fragilis and gut anaerobes

•  Pseudomonas and other more resistant gram negatives

•  ESBL or AmpC producing Enterobacteriaceae

•  Listeria

•  Not the agent of choice for Staphylococcal infections - prefer 1st generation cephalosporin