Low
Excellent
Oral: <$1/day
IV: nonform - $326/day
4 mg/kg load followed by 2 mg/kg every 12 hours up to 100 mg every 12 hours
For serious Acinetobacter infections may consider up to 400 mg/day
Dosing is the same for oral and intravenous
100 mg every 12 hours
For very serious infections, consider 200 mg loading dose, then 100 mg every 12 hours
For serious Acinetobacter infections may consider up to 400 mg/day
Dosing is the same for oral and intravenous
Intravenous agent is nonformulary and very expensive - reserve for serious infections where other options are not available or cystic fibrosis patients with Stenotrophomonas
Stenotrophomonas maltophila infections
Mild Staphylococcal infections (SSTIs) or suppression
Acne
Multidrug resistant Acinetobacter spp infections
Vertigo and ataxia
GI intolerance (dose related)
Worsening azotemia in patient with renal failure
Hepatotoxicity
Esophageal irritation
Photosensitivity
Skin and mucosal hyperpigmentation (blue-black, kind of grayish) with long term use
Pseudotumor cerebri (rare)
Lupus-like syndrome manifested by arthralgia, myalgia
Aggravation of myasthenia gravis
