Spectrum: Local Antimicrobial Stewardship, for IWK Health Centre

Necrotizing Enterocolitis (NEC)

Most likely pathogens

Escherichia coli

Enterobacter spp.

Klebsiella pneumoniae

Anaerobes

Enterococcus

Duration of therapy

7 to 14 days (unless the course is complicated by abdominal abscess formation). Tailor treatment based on organisms and clinical response.

Regimen

Ampicillin

AND

Gentamicin

AND

Metronidazole