Spectrum: Local Antimicrobial Stewardship, for IWK Health Centre

Ampicillin

C. diff Risk

Low

Oral Bioavailability

NA

Approximate Cost

$35/day

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Women's Health

General Pediatric

Neonatal

Renal

Renally cleared, requires dosage adjustment with changes in renal function. Consult a pharmacist for renal dosing.

General Information

Common Usage

Common Usage

Pathogen directed therapy for CNS, intravascular, intraabdominal, urinary and other infections esp enterococcus and listeria. As part of empiric therapy for early onset sepsis in neonates.

Drug Monitoring

Drug Monitoring

  • Renal

  • Liver function

  • CBC with differential

Adverse Effects

Adverse Effects

  • Allergy and rash

  • EBV related rash (not allergy)

  • Rare: cytopenias, +ve Coombs

Pharmacology

Pharmacology

Antimicrobial class: Aminopenicillin

Average serum half life:

  • Neonates
    PNA 2-7days: 4 hours
    PNA 8-14 days: 2.8 hours
    PNA 15-30 days: 1.7 hour

  • Pediatrics: 1-1.8 hours

  • Anuric patients: 8-20 hours

Route of Elimination:

  • 90% excreted unchanged in urine within 24 hours

  • Excreted in bile.