Spectrum: Local Antimicrobial Stewardship, for IWK Health Centre

Inpatient

Most likely pathogens

Consult

Infectious Diseases

Duration of therapy

7-10 days

Bacteremia: 10-14 days

Synovitis: 28 days

Osteomyelitis: at least 6 weeks

Suggested regimen

Dosing is based on piperacillin component:
Piperacillin-tazobactam 240-300 mg/kg/24h IV divided q6-8h
Maximum: 4 grams/dose and 16 grams/24h

Penicillin allergy

Clindamycin 25-40 mg/kg/24h IV divided q6-8h
Maximum: 900 mg/dose

AND

Dosing is based on trimethoprim component:
Co-trimoxazole 4-6 mg/kg/dose IV q12h