Spectrum: Local Antimicrobial Stewardship, for IWK Health Centre

Neonatal Acyclovir Dosing

General Dosing including CNS

Post natal age less than or equal to 7 days AND
less than or equal to 2 kg:
Acyclovir 20 mg/kg/dose IV q12h

Post natal age 8 days or greater AND
less than or equal to 2 kg:
Acyclovir 20 mg/kg/dose IV q8h

Patients greater than 2 kg regardless of post natal age:
Acyclovir 20 mg/kg/dose IV q8h

Herpes Simplex Virus (HSV); Localized Skin, Eye, Mouth (SEM)

HSV; Localized SEM

Suppressive Therapy Following Parenteral Therapy for HSV CNS /Disseminated / SEM Disease

Acyclovir 300 mg/m²/dose PO q8h X 6 months

Consult Infectious Diseases.
Monitor monthly CBC, urea, creatinine and weight (for dose adjustment).