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Pathogens
Antimicrobials
Herpes Simplex Virus
14 days
Less than or equal to 2 kg AND post natal age less than or equal to 7 days :
Acyclovir 20 mg/kg/dose IV q12h
Greater than 2 kg regardless of post natal age:
Acyclovir 20 mg/kg/dose IV q8h
Neonatal suppressive therapy following parenteral therapy for SEM disease may be offered, consult Infectious Diseases)
Acyclovir 300 mg/m²/ dose PO TID X 6 months Monitor monthly CBC, urea, creatinine and weight (for dose adjustment).