Medium
Excellent
$2/day
Renally cleared, requires dosage adjustment with changes in renal function. Consult a pharmacist for renal dosing.
Prophylaxis and treatment of bite wounds
Polymicrobial infections of the respiratory tract or abdomen
Skin and soft tissue infections
Diarrhea (common)
Allergy/rash
Cytopenias
Hepatotoxicity due to clavulanate is usually mild. EBV related rash (not allergy)
Concentration: 125 mg/31.25 mg
Each 1 mL contains: Amoxicillin 25 mg and Clavulanic Acid 6.25 mg (4:1 ratio)
Stable for 10 days in refrigerator after reconstitution.
Concentration: 400 mg/57 mg
Each 1 mL contains: Amoxicillin 80 mg and Clavulanic Acid 11.4 mg (7:1 ratio)
Stable for 7 days in refrigerator after reconstitution.
Taste: Palatable
Not all strengths of oral liquids are listed nor are available on IWK formulary
Tablet 250/125 mg
Containing: Amoxicillin 250 mg and Clavulanic Acid 125 mg (2:1 ratio)
Tablet 500/125 mg
Containing: Amoxicillin 500 mg and Clavulanic Acid 125 mg (4:1 ratio)
Tablets and capsules are preferred especially over an unpleasant tasting liquid.
Not all strengths of oral tablets/capsules are listed and they are not all available on the IWK formulary.
Antimicrobial class: Aminopenicillin + Beta-lactamase inhibitor
Average serum half life: Adults: ~1 hour. Amoxicillin pharmacokinetics are not affected by clavulanic acid
Route of Elimination: Urine (amoxicillin 50% to 70% unchanged drug; clavulanic acid 25% to 40% unchanged drug)
