Spectrum: Local Antimicrobial Stewardship, for IWK Health Centre

Amoxicillin

C. diff Risk

Low

Oral Bioavailability

Excellent

Approximate Cost

$0.50/day

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

Dosing

Women's Health

General Pediatric

Neonatal

Renal

Renally cleared, requires dosage adjustment with changes in renal function. Consult a pharmacist for renal dosing.

General Information

Common Usage

Common Usage

Therapy of streptococcal, enterococcal infections as well as susceptible gram negative infections.

Commonly used for upper respiratory infections and urinary tract infection (when organisms susceptible)

Adverse Effects

Adverse Effects

  • Allergy/rash (immediate or delayed)

  • Cytopenias

  • EBV related rash (not allergy)

Oral Liquids

Oral Liquids

Concentration: 50 mg/mL
Taste: very palatable
Not all strengths of oral liquids are listed nor are available on IWK formulary

Tablet/Capsule Strengths

Tablet/Capsule Strengths

250 mg capsule 500 mg capsule
Tablets and capsules are preferred especially over an unpleasant tasting liquid. Not all strengths of oral tablets/capsules are listed and they are not all available on the IWK formulary.

Pharmacology

Pharmacology

Antimicrobial class: Aminopenicillin

Average serum half life: Neonates, full-term: 3.7 hours
Infants and children: 1 to 2 hours

Route of Elimination: Renal excretion (60% unchanged drug)