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Guidelines
Pathogens
Antimicrobials
High
NA
$30/day
Renally cleared, requires dosage adjustment with changes in renal function. Consult a pharmacist for renal dosing.
Empiric therapy for bacterial meningitis, pneumonia, intra-abdominal infection (with metronidazole), and urinary tract infection
Rash
Localized phlebitis at injection site
Allergy
Positive Coombs test
Neutropenia
Diarrhea
Preferred cephalosporin in neonates
Antimicrobial class: 3rd Generation Cephalosporin
Average serum half life:
Neonates: 3.4-4.6 hours
Children: 1.5 hours
Route of Elimination: urine: ~60% as unchanged drug and metabolites in urine