Fever in Asplenic/Sickle Cell Patients

Patient showing signs of shock

Ceftriaxone IV/IM 100 mg/kg/day divided q12-24 hrs

Give q12 for meningitis/CNS infections.
Max 4g/day.

AND

Vancomycin IV 60 mg/kg/day divided q6-8 hrs.

Usual maximum starting dose 4g/day.
Dose should be adjusted based on serum drug level monitoring