Spectrum: Local Antimicrobial Stewardship, for Alberta Children's Hospital

Ceftriaxone

C. diff Risk

High

Oral Bioavailability

NA

Approximate Cost

$3/day

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Hepatic

If patient has renal and hepatic impairment, do not exceed doses of 2g/day

Neonatal

Cefotaxime is preferred in neonates.If necessary, ceftriaxone can be given at a dose of 50 mg/kg q24h.

IV Mild/Moderate

IV,IM: 50-75mg/kg/DAY given as a single daily dose. Max: 4g/day.

IV Severe

IV, IM: 100mg/kg/DAY divided q12-24h.
(Give q12h for meningitis & CNS infection)
Max: 4g/day.

General Information

Common Usage

Common Usage

Empiric therapy of bacterial meningitis

Empiric therapy of nosocomial Gram negative infections (except Pseudomonas)

Adverse Effects

Adverse Effects

  • Allergy/rash (immediate or delayed).

  • Cytopenias, eosinophilia, and hepatic and renal laboratory abnormalities

  • Pseudocholelithiasis.

Major Interactions

Major Interactions

Calcium containing IV solutions bind to ceftriaxone forming an insoluble precipitate- avoid concurrent use with calcium contaning colutions in neonates.

Additional Information

Additional Information

IM ceftriaxone may be given with 1% lidocaine to minimize pain at injection site

Pharmacology

Pharmacology

Antimicrobial class: Parenteral Cephalosporin - 3rd Generation

Average serum half life:

  • Neonates: 1-4 days: 16 hours; 9-30 days: 9 hours

  • Pediatrics: 4.1-6.6h

Route of Elimination: unchanged in the urine (33-67%) by glomerular filtration and in feces via bile.