Spectrum: Local Antimicrobial Stewardship, for Alberta Children's Hospital

Peramivir

Special Access

Peramivir is only available through a Special Access Process, and whereas only licensed for adults, some pediatric dosing is available. Please contact Infectious Diseases service and pharmacy.

Usual Route of Administration

Intravenous

Dose Adjustment on Renal Impairmant

Yes. Depends on creatinine clearance.

Adverse Events

More Common

  • Diarrhea

  • Nausea

  • Vomiting

Less Common

  • Neutropenia

  • Post-marketing reports of serious skin reactions and sporadic, transient neuropsychiatric events (self-injury or delirium; mainly reported among Japanese adolescents and adults).

Comments

Approved for use in the USA, but not for prophylaxis or uncomplicated illness.

Approved for adults only in Canada.

Current Health Canada indications are only for individuals 18 years and older, as a single 600 mg IV dose.