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Guidelines
Pathogens
Antimicrobials
May be treated with oral or initial parenteral agent[s]
Vancomycin (Dosing per pharmacy)
PLUS
Piperacillin/tazobactam (extended 4-hr infusion) 3.375 g IV q8h
OR
Ertapenem 1g IV q24h
Ciprofloxacin 400 mg IV q12h
Metronidazole 500 mg IV q8h
Duration of treatment will depend on rapidity of response, presence of adequate blood supply, need for surgical debridement and/or diagnosis of osteomyelitis.
Duration of treatment can likely be shortened with adequate surgical intervention (7-10 days post-op); a longer will be needed for osteomyelitis (6-8 weeks).
Change to an oral regimen when patient is stable.