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Antimicrobials
Antimicrobial therapy should be tailored once susceptibilities are known.
Vancomycin should be stopped if resistant Gram-positive organisms (MRSA) are not recovered.
Gram-negative coverage can be reduced to a single susceptible agent in most cases.
The benefits of combination therapy in the treatment of Pseudomonas VAP are not well-documented. If it is desired, then combination therapy should be given for the first 5 days of therapy only
Double Coverage of Gram Negative Organisms
If Pseudomonas is not recovered, reduce the dose. For example:
Cefepime 1g IV q8h
Ciprofloxacin 400 mg IV q12h
