Spectrum: Local Antimicrobial Stewardship, for Markham Stouffville Hospital

Streptococcus pneumoniae

Pneumonia

Ceftriaxone 1-2g Q24H

Meningitis

Vancomycin 15-20 mg/kg IV Q8-12H

Dose to a target trough level of 15-20mg/L

PLUS

Ceftriaxone 2g IV Q12H

Endocarditis

Vancomycin 15-20mg/kg IV Q8-12H

Dose to a target trough level of 15-20mg/L

PLUS

Ceftriaxone 2g IV Q24H

Duration of Therapy

Pneumonia and Meningitis
10-14 days if uncomplicated

Endocarditis
Up to 6 weeks

Comments

Most common source is pneumonia, meningitis, or endocarditis.
Tailor empiric therapy based on sensitivities