Spectrum: Local Antimicrobial Stewardship, for Markham Stouffville Hospital

Prosthetic Valve (Early)

Duration

6 Weeks

Antibiotic Regimen

Vancomycin 15-20 mg/kg IV q8-12h

Dose should be adjusted to obtain

serum trough levels of 15-20 mg/L. Peak levels are not routinely indicated.

PLUS

Ceftriaxone 2 g IV q12h

PLUS

Rifampin 300 mg PO q8h

Patients Unable to Tolerate Ceftriaxone

Vancomycin 15-20 mg/kg IV q8-12h

Dose should be adjusted to obtain

serum trough levels of 15-20 mg/L. Peak levels are not routinely indicated.

PLUS

Gentamicin 1 mg/kg IV q8h

PLUS

Rifampin 300 mg PO q8h