Spectrum: Local Antimicrobial Stewardship, for Markham Stouffville Hospital

Early-Onset Bacteremia or Sepsis

Duration of Therapy

10 days

Transition from empiric to definitive therapy should occur once GBS is identified by culture and clinical improvement is evident.

Empiric Therapy

Ampicillin

0-7 Days of Age

2 kg or less
50 mg/kg IV q12h

Over 2 kg
50 mg/kg IV q8h

PLUS

Gentamicin

0-7 Days of Age

PMA Less Than 34 Weeks
3 mg/kg IV q24h

PMA 34 Weeks or More
3 mg/kg IV q18h

Definitive Therapy

Penicillin G

0-7 Days of Age

2 kg or less
25,000 units/kg IV/IM q12h

Over 2 kg
25,000 units/kg IV/IM q8h