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Guidelines
Pathogens
Antimicrobials
Greater than or equal to 21 Days
Ampicillin 2g IV q4h
PLUS EITHER
Gentamicin* 1.7 mg/kg IV q8h
for 3-7 days.
*Synergy with beta-lactam
OR
Tobramycin* 1.7 mg/kg IV q8h
for 3-7 days
TMP-SMX 5mg/kg IV q6h
If the patient has a true history of IgE mediated penicillin or beta-lactam allergy, the risks versus benefit of empiric treatment of suspected meningitis with appropriate antimicrobials should be discussed.
Refer to Beta-lactam allergy algorithm.
