Neisseria meningitides (Adults)

Duration of Therapy

7 Days

If Penicillin MIC less than or equal to 0.1 mcg/mL

Penicillin G, 4 million units IV q4h

If Penicillin MIC 0.1 to 1 mcg/mL

Ceftriaxone 2g IV q12h

Beta-lactam Allergy

Moxifloxacin 400mg IV q24h

Penicillin/Beta-lactam Allergy

If the patient has a true history of IgE mediated penicillin or beta-lactam allergy, the risks versus benefit of empiric treatment of suspected meningitis with appropriate antimicrobials should be discussed.