GBS or Streptococcus agalactiae (Neonates)

14-21 Days

Maintain empiric therapy until documentation of sterile blood and CSF cultures, then may switch to definitive therapy below

0-7 Days of Age
80,000-150,000 units/kg IV/IM q8h

8-28 Days of Age
112,000 units/kg IV/IM q6h

0-7 Days of Age
67 mg/kg IV q8h

8-28 Days of Age
75 mg/kg IV q6h

0-7 Days of Age

Less than 2 kg
50 mg/kg IV/IM q12h

Greater than 2 kg
50 mg/kg IV/IM q8h-q12h

8-28 Days of Age

Less than 1.2 kg
50 mg/kg IV/IM q12h

Between 1.2-2 kg
50 mg/kg IV/IM q8h

Greater than 2 kg
50 mg/kg IV/IM q6h-q8h

If the patient has a true history of IgE mediated penicillin allergy, the risks versus benefit of empiric treatment of suspected meningitis with appropriate antimicrobials should be discussed.