Listeria monocytogenes (Neonates)

Greater than or equal to 21 Days

0-7 Days
67 mg/kg IV q8h

8-28 Days
75 mg/kg IV q6h

0-7 Days
Less than 34 weeks PMA: 3 mg/kg IV q24h
Greater than or equal to 34 weeks PMA: 3 mg/kg IV q18h

8-28 Days
1 kg or less : 3.5 mg/kg IV q24h
Over 1 kg and less than 37 weeks PMA:
2.5 mg/kg IV q12h
Over 1 kg and greater than or equal to 37 weeks PMA: 2.5 mg/kg IV q8h

Note
Need to monitor peak and trough serum concentrations.

0-7 Days
Less than 34 weeks PMA: 3 mg/kg IV q24h
Greater than or equal to 34 weeks PMA: 3 mg/kg IV q18h

8-28 Days
1 kg or less : 3.5 mg/kg IV q24h
Over 1 kg and less than 37 weeks PMA:
2.5mg/kg IV q12h
Over 1 kg and greater than or equal to 37 weeks PMA: 2.5 mg/kg IV q8h

Note
Need to monitor peak and trough serum concentrations.

Use in infants less than 2 months remains controversial – most experts believe there is no risk of kernicterus in well patients greater than 4 weeks of age, and many would also use in infants 2-4 weeks old with no signs of jaundice

If the patient has a true history of IgE mediated penicillin or beta-lactam allergy, the risks versus benefit of empiric treatment of suspected meningitis with appropriate antimicrobials should be discussed.