Gram-negative bacilli (Infants and Children)

21 Days

Greater than 1 month of age
100 mg/kg IV at 0, 12, and 24 h followed by 100 mg/kg IV q24h or 50 mg/kg IV q12h

Dose limit: 4 g/day (2 g/dose)

50 mg/kg IV q8h

5mg/kg IV q6h

Dose based on trimethoprim component

If the patient has a true history of IgE mediated penicillin allergy, the risks versus benefit of empiric treatment of suspected meningitis with appropriate antimicrobials should be discussed.