Listeria monocytogenes (Infants and Children)

Duration of Therapy

Greater than or equal to 21 Days

Regimen of Choice

Ampicillin
50-100 mg/kg IV q6h
Max 3 g/dose (12 g/day)

PLUS EITHER

Gentamicin 1 mg/kg IV q8h

For 3 - 7 days
Need to monitor peak and trough serum concentrations
Synergy with beta-lactams for gram positive infections

OR

Tobramycin 1 mg/kg IV q8h

For 3 - 7 days
Need to monitor peak and trough serum concentrations
Synergy with beta-lactams for gram positive infections

PCN Allergy

TMP-SMX 5mg/kg IV q6h

Dosage based on trimethoprim component

Penicillin/Beta-lactam Allergy

If the patient has a true history of IgE mediated penicillin or beta-lactam allergy, the risks versus benefit of empiric treatment of suspected meningitis with appropriate antimicrobials should be discussed.