Spectrum: Local Antimicrobial Stewardship, for Markham Stouffville Hospital

Hematogenous Osteomyelitis - Over 3 Months

Common Pathogens

Staphyloccocus aureus

MRSA Risk Factors:

  • Evidence of MRSA infection elsewhere

  • Nasal colonization with MRSA

  • Injection drug use

Streptococcus pyogenes (Group A β-hemolytic streptococci)

Enterobacteriaceae

Haemophilus influenzae

Streptococcus pneumoniae

Empiric IV Antimicrobial Regimen

Cefazolin 35-50mg/kg IV Q8H
Max 6g/day, 2g/dose

MRSA Risk Factors Present

Vancomycin 15 mg/kg IV Q6H