Spectrum: Local Antimicrobial Stewardship, for Markham Stouffville Hospital

Amoxicillin-Clavulanate Dosing

Adults

875/125mg po BID

Children (3m and Older)

38 kg and Under

  • 13mg amoxicillin component/kg/dose PO q8h OR

  • 20mg amoxicillin/kg/dose PO q12h

Over 38 kg

500mg PO q8h
Max: 250-875mg/dose of amoxicillin

Infants less than 3 months

15 mg amoxicillin/kg/dose PO q12h given as 40 mg/mL suspension

Neonates

  • Dosing based on amoxicillin component

  • Dose and frequency are product specific

  • Not all products are interchangeable

  • Using a product with the incorrect amoxicillin:clavulanate ratio could result in subtherapeutic clavulanate concentrations or severe diarrhea.

General Dosing, Susceptible Infection

Oral
15 mg amoxicillin/kg/day every 12 hours using the 200 mg/5 ml suspension only