Spectrum: Local Antimicrobial Stewardship, for Bakersfield Memorial Hospital

Perforated, Critically Ill

Empiric Therapy

Zosyn 3.375 g IV every 8hr (4 hr infusion)

Oral Stepdown

Amoxicillin/Clavulanate 875 mg PO BID

PCN Allergy

Tobramycin 5 mg/kg IV every 24 hr

PLUS

Metronidazole 500 mg IV every 8hr

Duration

5 - 7 days