Spectrum: Local Antimicrobial Stewardship, for Bakersfield Memorial Hospital

Amoxicillin-Clavulanate

C. diff Risk

Medium

Oral Bioavailability

Excellent

Approximate Cost

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

Dosing

Renal

Adult

875mg PO BID or 500mg PO TID of the amoxicillin component

Pediatric

General Information

Common Usage

Common Usage

Prophylaxis/treatment of bite wounds.

Polymicrobial infections of the respiratory tract or abdomen.

Skin and soft tissue infections.

Drug Monitoring

Drug Monitoring

For prolonged therapy, monitor liver enzymes and function.

Adverse Effects

Adverse Effects

  •  Allergy/rash (immediate or delayed)

  •  Note EBV related rash

  •  Diarrhea

  •  Hepatotoxicity due to clavulinate - usually mild, liver failure is rare.

Major Interactions

Major Interactions

Increased risk of rash with allopurinol

Pharmacology

Pharmacology

Antimicrobial class: Aminopenicillin + Beta-lactamase inhibitor

Pregnancy category: B

Average serum half life: 1 hour

Biliary penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic