Spectrum: Local Antimicrobial Stewardship, for Eastern Health

Hematogenous Osteomyelitis - Adolescents and Adults

Common Pathogens

Staphyloccocus aureus

MRSA Risk Factors:

  • Evidence of MRSA infection elsewhere

  • Nasal colonization with MRSA

  • Injection drug use

Enterobacteriaceae

Empiric IV Antimicrobial Regimen

Cefazolin 2g IV Q8H

MRSA Risk Factors Present

Vancomycin IV loading dose followed by maintenance for target trough of 15-20 ug/mL
see dosing nomogram

If patient cannot be dosed using nomogram
contact Pharmacy.