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Antimicrobials
Enterococcal IE is generally treated for SIX weeks, and maybe longer for prosthetic valves
Gentamicin is generally continued for the duration of therapy but needs to be weighed against toxicities
The course starts from the first negative blood culture, and may require alteration if complications occur or the patient requires surgery/valve replacement
Vancomycin IV loading dose followed by maintenance for target trough of 15-20 ug/mL see dosing nomogram
If patient cannot be dosed using nomogram contact Pharmacy.
AND
Gentamicin 1mg/kg IV q8h (trough <1µg/mL)
This regimen has significant risk of nephrotoxicity; close monitoring required. Pharmacy consult recommended.
Day 3 Bundle
