Spectrum: Local Antimicrobial Stewardship, for Eastern Health

Second or further recurrence

Treatment

Tapered or pulsed Vancomycin PO, such as:
Following the usual dosage of 125 mg QID for 10–14d, give 125 mg BID for 7d, 125 mg OD for 7d, and then 125 mg q2-3 days for 2–8 weeks

OR

Vancomycin 125mg PO QID x 10 days

FOLLOWED BY

Rifaximin 550 mg PO TID for 20 days
(400 mg tablets not available in Canada)

OR

Fidaxomicin 200mg PO BID x 10 days