Spectrum: Local Antimicrobial Stewardship, for Eastern Health

Fidaxomicin

C. diff Risk

None

Oral Bioavailability

None

Approximate Cost

$189.20/day

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

Dosing

Renal

No dosage adjustment necessary (minimal systemic absorption)

No supplemental doses required for HD

Adult

C. difficile
200mg po BID x 10days

General Information

Acceptable Uses

Acceptable Uses

First line therapy for first episode or recurrent CDAD

NOTE: NLPDP and Eastern Health Criteria for use differ

See Eastern Health CDAD Treatment Guidelines for more information

Common Usage

Common Usage

C. difficile colitis

Adverse Effects

Adverse Effects

  •  GI disturbance

  •  Cytopenias

  •  Hypersensitivity: facial, tongue or throat swelling

Coverage

NLPDP Status

SPECIAL AUTHORIZATION REQUIRED

Additional Information

Additional Information

EH Prescribing Restrictions
None

NLPDP Status
Special Authorization required
More Information

See Eastern Health CDAD treatment guidelines for therapy recommendations.

Pharmacology

Pharmacology

Antimicrobial class: Specialized anti-C. difficile macrocyclic agent

Pregnancy category: B

Urine penetration: None

Lung penetration: None

CSF penetration: None

Biliary penetration: None