Spectrum: Local Antimicrobial Stewardship, for Providence Health Care

Oral stepdown

Patient must be clinically improving prior to step-down (Lower drug levels achieved with oral dosage form of same drug)

Acyclovir IV

Valacyclovir - dose based on indication

Ampicillin IV

Amoxicillin 250 to 500 mg PO TID
(1 g PO TID severe)

Azithromycin IV

Clarithromycin XL 500 to 1000 mg PO daily

Azithromycin 250 to 500 mg PO daily

Cefazolin IV

Cephalexin 250 to 500 mg PO QID
(1 g PO QID severe)

Cefuroxime IV

Cefuroxime axetil 250 to 500 mg PO BID (TID severe)

Penicillin G IV

Penicillin VK 300 to 600 mg PO QID (mild infections only)