Medium
Moderate
CYP450 interactions ++
Other QTc prolonging agents
Recommend review of pt medications due to high frequency of significant interactions
Statins - increased rhabdo
CCBs - hypotension, AKI
Colchicine - increased bone marrow toxicity
Increased tacrolimus levels
Increased phenytoin levels
Increased INR with warfarin
Very high tissue penetration and concentration intracellularly means in vivo activity may not be predicted by in vitro testing
May exacerbate muscle weakness in persons with myasthenia gravis. Avoid Use.
Antimicrobial class: Macrolide
Pregnancy category: C
Average serum half life: 5.0
Biliary penetration: Therapeutic
CSF penetration: Poor
Lung penetration: Therapeutic
Urine penetration: Poor
