Spectrum: Local Antimicrobial Stewardship, for Chapman University School of Pharmacy

Polymyxin B

Oral Bioavailability

NA

Approximate Cost

Dosing

Adult

Loading dose: 20,000-25,000 IU/kg x1
Maintenance dose: 25,000-30,000 IU/kg/day in 2 divided doses

General Information

Adverse Effects

Adverse Effects

  • Nephrotoxicity

  • Neurotoxicity

  • Parasthesias

  • Electrolyte abnormalities

Pharmacology

Pharmacology

Pharmacology: Increases cell membrane permeability

Antimicrobial class: Polymyxin

Pregnancy category: b

Average serum half life: 6 hours

Urine penetration: Poor