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Antimicrobials
Begin by calculating the Early Clinical Failure Score
These criteria are evaluated after 72-96 hours of gram-negative BSI.
Basis for Recommendations
A “one-size-fits-all” treatment duration for gram-negative bloodstream infections (BSI) does not fit our high standards of antimicrobial therapy in the era of precision medicine.
These customized treatment durations are derived from a recent clinical trial results and re-analysis of our local data after stratification based on clinical response to antimicrobial therapy within the first 4 days of BSI.
Systolic blood pressure <100 mmHg or vasopressor use
Heart rate >100 beats/minute
Respiratory rate ≥22 breaths/minute or mechanical ventilation
Altered mental status from baseline
Peripheral white blood cell count >12,000/mm³
