Spectrum: Local Antimicrobial Stewardship, for Prisma Health-Midlands

Susceptibility-Testing

Typical Gram-positive Bacteria

Streptococcus pneumoniae

IV

  • Penicillin G

  • Ampicillin

  • Ampicillin/sulbactam

  • Ceftriaxone

PO

  • Amoxicillin

  • Amoxicillin-clavulanate

Typical Gram-negative Bacteria

Haemophilus influenzae, Moraxella catarrhalis

IV

  • Ampicillin

  • Ampicillin/sulbactam

  • Ceftriaxone

PO

  • Amoxicillin

  • Amoxicillin-clavulanate

Atypical Bacteria

Legionella spp

IV

  • Levofloxacin

  • Azithromycin

PO

  • Levofloxacin

  • Azithromycin

Chlamydia (Chlamydophila) pneumoniae, Mycoplasma pneumoniae

IV

  • Azithromycin

  • Doxycycline

PO

  • Azithromycin

  • Doxycycline

Staphylococcus aureus

MSSA

IV

  • Nafcillin

  • Cefazolin

PO

  • Dicloxacillin

  • Cephalexin

MRSA

IV

  • Vancomycin

  • Linezolid

PO

  • Doxycycline

  • SMZ-TMP

  • Clindamycin

  • Linezolid

Enterobacteriaceae

Escherichia coli, Klebsiella pneumoniae, Klebsiella oxytoca, Proteus mirabilis

IV

  • Ampicillin

  • Ampicillin/sulbactam

  • Cefazolin

  • Ceftriaxone

PO

  • Amoxicillin

  • Amoxicillin-clavulanate

  • Cephalexin

  • Levofloxacin

Other Enterobacteriaceae (with potential chromosomal AmpC production)

Enterobacter cloacae, Klebsiella (formerly Enterobacter) aerogenes, Serratia marcescens

IV

  • Cefepime

PO

  • Levofloxacin

Non-Lactose-Fermenting Gram-negative Bacteria

Pseudomonas aeruginosa, Acinetobacter baumannii

IV

  • Cefepime

  • Piperacillin-tazobactam

PO

  • Ciprofloxacin

  • Levofloxacin